Yes. Click Select to display checkboxes on the left-hand side for you to select the documents/emails to delete. You can then checkmark the documents/emails you want to delete, or click the checkbox in the column heading to select all. Then click Delete to delete the selected documents/emails.
You can also use Bulk Update to file multiple documents/emails in your In Tray at the same time.
Refer also to Working with Filed Documents and Emails.